Gluten Sensitivity

From Non-Celiac Gluten Sensitivity:
How to Diagnose and Differentiate it from Celiac Disease


  • Non-Celiac Gluten Sensitivity can present with intestinal and extra-intestinal symptoms
  • There are no biomarkers for diagnosis
  • Autoantibodies (TTG, EMA, DGP) are absent
  • There is no villous atrophy
  • Diagnosis requires excluding celiac disease by serological tests
  • A gluten-free diet should not be started before ruling out celiac disease
  • The gluten-free diet is complicated and expensive
  • Patients should be referred to a dietitian with expertise in the gluten-free diet.

Take Home Message

What is most important for the public and health care professionals to know is that the diagnosis of
non-celiac gluten sensitivity should not be made without excluding celiac disease. A gluten-free diet
should NOT be initiated without a proper clinical assessment that includes serological testing with
IgA-tissue transglutaminase antibody while the individual is on a regular gluten-containing diet.

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