Celiac Disease Research
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A study for individuals with celiac disease is open at the University of Alberta. This study is looking to recruit people who are following a gluten-free diet but are still having symptoms. The research is to look at whether a new product, called AGY, can reduce or eliminate the symptoms associated with gluten exposure. The study will also evaluate the safety of AGY and its effect on quality of life.
A previous study of 10 adults treated with AGY for 4 weeks showed encouraging results. The current study will evaluate AGY in a larger group of people.
Eligible participants would need to:
- Be between 10 and 65 years old
- Have medically diagnosed Celiac Disease at least 12 months before study enrollment.
- Experience periodic, mild to moderate, celiac symptoms despite following a gluten free diet for the last 12 months.
- Be willing to complete several questionnaires (some daily), undergo periodic lab work and urine testing
- Not be allergic to eggs
- Either visit the university 6 times over approximately 16 weeks, or participate remotely
- Willing to sign consent/assent and follow all study procedures
If you are interested in learning more about this study, please contact:
Dory Sample at 780-248-5599, dsample@ualberta.ca
Shelley M Case RD, Donald R Duerksen MD FRCPC, Melissa Secord CAE
Reading ingredient lists and labelling claims are essential to determine the safety of foods for individuals on a gluten-free diet (GFD). The complexities of food labelling, how manufacturers convey gluten contamination risk and what appears on product packages can be challenging for consumers to understand and make informed safe choices.
The Canadian Celiac Association (CCA) conducted an online labelling survey to gauge understanding about precautionary statements (PS) and other claims on labels for those with celiac disease (CD), not diagnosed with CD who follow a GFD, caregivers/parents and dietitians.
Click to Review the Survey Results and Conclusions
Introduction of Gluten-Free Oats in the Gluten-Free Diet of Children and Adults with Celiac Disease: An International Survey
Shelley M Case RD, Caleigh E McAulay, MSc Nutrition Science, Vanessa G Ramouche, Dominica A Gidrewicz, MD
Guidelines highlight that pure uncontaminated gluten-free oats (GFO) are considered safe as part of the strict gluten-free diet (GFD) to treat celiac disease (CD). Yet controversy amongst clinicians exists as to the timing of introducing GFO, in clinical remission versus newly diagnosed versus other. Members of the celiac community want to consume GFO as part of a healthy balanced GFD and want to understand when it is safe to do so.
This purpose of this survey was to evaluate current recommendations from around the world about the:
- Timing of introducing GFO
- Type of oats recommended
- Follow-up approaches for children and adults after GFO introduction
- The goal of further research is to create safe and effective recommendations for clinicians and reduce confusion in the CD community.
Click to Review the Poster and Conclusions
Assessment of Availability of Safe Gluten-Free Diet to Residents of Long-Term Care Facilities
Zaynab Al-Nuaimi, RD, Melissa Secord, CAE, Dr. Mohsin Rashid
Treatment of celiac disease is a strict, lifelong gluten-free diet (GF diet). Individuals with celiac disease in long-term care (LTC) facilities may be vulnerable to gluten cross-contamination as they might lack means of advocating for themselves.
The aim of the study was to identify gaps involved in provision of safe GF diet to residents in LTC facilities.
Click to Review the Poster and findings
Dr. Diana Mager from the University of Alberta speaks with Sue Jennett, of a Canadian Celiac Podcast, about her Conquer study on a food guide for celiac kids.
Listen to the 2021 Virtual Conference Sessions (November, 2021)
The economic and social costs of the gluten-free diet
With support from a James A Campbell Grant, University of Manitoba researcher sheds a light on the economic, social and health cost of the gluten-free diet.
Pediatric Celiac Symptom Index – Improving Patient Outcomes
Dowhaniuk and Walsh work to improve pediatric celiac patients’ journeys with new tool funded by CCA James A. Campbell Grant.
Click to learn more
CCA partners with McMaster University on gluten free on campus (May 2021)
Access to gluten-free diet across Canadian Universities and Colleges
Students currently attending a Canadian University or College who may have been diagnosed with CD, non-celiac-gluten sensitivity (NCGS) or follow a gluten-free diet (GFD) for another reason are invited to participate.
As the number of individuals adhering to a gluten-free diet rises, there is a need to identify barriers that students adopting a GFD face on campus at Canadian universities to ease their access to viable gluten-free options. Our hope is that this survey will help us understand more about the challenges faced by students adopting a GFD in Canada, further contributing towards more education in the near future.
This survey will take approximately 3 minutes to complete. This collaborative research study survey conducted by clinicians and researchers from McMaster University and the Canadian Celiac Association.
Current and emerging trends in coeliac disease. (November 24, 2020)
More turkey dinners for people with celiac disease? (October 2020)
Researchers find combo of tryptophan with probiotics may help them heal
The risk of contracting COVID-19 is not increased in patients with celiac disease
This past spring CCA along with many patient organizations across the world participated in a study of patients with celiac disease (CeD) and their experience and knowledge of COVID-19. Numerous studies suggest that celiac disease (CeD) is associated with an increased risk of respiratory infections. However, how it relates to the risk of COVID-19 is unknown. To address this gap, the investigators conducted a cross-sectional study to evaluate whether patients with self-reported CeD are at an increased risk of contracting COVID-19. Patients were asked to complete an online survey and a total of 18,000 individuals participated. The Canadian celiac community represented the vast majority of participants in the study and we thank them for their participation. The study concluded that patients with CeD have similar odds of contracting COVID-19 and may not need to take additional precautions to prevent exposure aside from the recommended to the general public. Longitudinal studies employing repeated measurements will contribute to a better understanding on whether the risk of contracting COVID-19 in CeD changes over time.
-October 11, 2020
CCA surveyed thousands of Canadians with celiac to see what they know about oats.
-May 2020
Organic pollutants and increased risk of celiac disease
-May 2020
In a systematic review and meta-analysis, the study found an increased risk of IBD in patients with celiac disease and increased risk of celiac disease in patients with IBD, compared with other patient populations. High-quality prospective cohort studies are needed to assess the risk of celiac disease-specific and IBD-specific biomarkers in patients with IBD and celiac disease.
-May 2020
Incidence of Celiac Disease Is Increasing Over Time: A Systematic Review and Meta-analysis
CCA Research grant winner James King lead an international meta-analysis on the growth of celiac disease.
Click here to watch a video presentation.
April 2020
Patients With Celiac Disease on Gluten-Free Diets Consume Measurable Amounts of Gluten – March 2020
This study received funding from CCA’s James A. Campbell Research Fund. Dr. Donald Duerksen. The Doggie Bag Study
Sheffield researchers confirm coeliac disease can damage the brain – February 2020
Undeclared Gluten in Products Containing Gluten-Free Oats – Canadian Food Inspection Agency Survey, published November 2019
European Clinical Practice Guidelines for Celiac Disease (ESPHGAN) – October 2019
Takeda acquires global license for investigational therapy for celiac disease following positive 2A clinical trial – October, 2019
Predicting Instestinal Healing – October, 2019
Cross-Contact Study – Do families really need two toasters?
– October 2019
Metabolism of wheat proteins by intestinal microbes: Implications for wheat related disorders – September 2019
Silent celiac disease common in relatives of patients – September, 2019
Celiac disease: should we care about microbes? – August 2019
Survey of the initial management of celiac disease antibody tests by ordering physicians
Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patient – March 2019
Assessment of the knowledge of the gluten-dree diet amongst food handlers in health care institution care facilities – March 2019
Normalization Time of Celiac Serology in Children on a Gluten-free Diet
Genetic Overlap Between Autoimmune Disease and NHL Not Supported by Genome-Wide Association Study
World’s first diagnostic blood test for celiac disease in sight
Why people with celiac disease suffer so soon after eating gluten
New study calls for screening of family members of celiac disease patients
Research publications by Professional Advisory Council,
Canadian Celiac Association (2003-2018)
Duerksen D, Pinto-Sanchez MI, Anca A, Schnetzler J, Case S, Zelin J, Smallwood A, Turner J, Verdu E, Butzner D, Rashid M. Management of Bone Health in Patients with Celiac Disease: A Practical Guide for Clinicians. Canadian Family Physician 2018 Jun;64(6):433:438 Click here for article
Pulido O, Zarkadas M, Dubois S, MacIsaac K, Cantin I, La Vieille S, Godefroy S, Rashid M. Clinical Features and Symptom Recovery on a Gluten-Free Diet in Canadian Adults with Celiac Disease. Canadian Journal of Gastroenterology 2013 Aug;27(8):449-453 Link to Abstract
Zarkadas M, Dubois S, Collins K, Cantin I, Rashid M, Roberts K, La vieille S, Godefroy S, Pulido O. Living with Celiac Disease and a Gluten-Free Diet: A Canadian Perspective. Journal of Human Nutrition & Dietetics 2013;26(1):10-23 Click here for study
Rashid M, Zarkadas M, Anca A, Limeback H. Oral Manifestations of Celiac Disease: A Clinical Guide for Dentists. Journal of Canadian Dental Association 2011 Apr;77:b39 Also reprinted in Journal of Michigan Dental Association 2011 Oct;93(10):42-6 and Journal of the Pierre Fauchard Academy (www.fauchard.org/) 2012, Mar/Apr;57(2):84-86 Click link to journal
Rashid M, Butzner JD, Warren R, Molloy M, Case S, Zarkadas M, Burrows V, Switzer C. Home Blood Testing for Celiac Disease: Recommendations for Management. Canadian Family Physician 2009 Feb;55:151-153 Link to abstract
Rashid M, Butzner JD, Burrows V, Zarkadas M, Case S, Molloy M, Warren R, Pulido O, Switzer C. Consumption of Pure Oats by Individuals with Celiac Disease: A Position Statement by the Canadian Celiac Association. Canadian Journal of Gastroenterology 2007 Oct;21(10):649-651
Cranney A, Zarkadas M, Graham ID, Butzner JD, Rashid M, Warren R, Molloy M, Case S, Burrows V, Switzer C. The Canadian Celiac Health Survey. Digestive Diseases & Sciences 2007;52(4):1087-1095 Canadian Celiac Health Survey
Zarkadas M, Cranney A, Case S, Molloy M, Switzer C, Graham ID, Butzner JD, Rashid M, Warren R, Burrows V. The Impact of A Gluten-Free Diet on Adults with Coeliac Disease: Results of a National Survey. Journal of Human Nutrition & Dietetics 2006;19:41-49
Rashid M, Cranney A, Zarkadas M, Graham ID, Switzer C, Case S, Molloy M, Warren R, Burrows V, Butzner JD. Celiac disease: Evaluation of the Diagnosis and Dietary Compliance in Canadian Children. Pediatrics 2005;116:e754-e759 Click here for article
Cranney A, Zarkadas M, Graham ID, Switzer C. The Canadian Celiac Health Survey-The Ottawa chapter pilot. BMC Gastroenterology 2003;3:8
